Dexmedetomidine is rapidly distributed and is mainly hepatically metabolized into inactive metabolites by glucuronidation and hydroxylation. Dexmedetomidine exerts its hypnotic action through activation of central pre- and postsynaptic α 2-receptors in the locus coeruleus, thereby inducting a state of unconsciousness similar to natural sleep, with the unique aspect that patients remain easily rousable and cooperative. Hemodynamic effects, which include transient hypertension, bradycardia, and hypotension, result from the drug’s peripheral vasoconstrictive and sympatholytic properties. It is potent and highly selective for α 2-receptors with an α 2:α 1 ratio of 1620:1. Dexmedetomidine is an α 2-adrenoceptor agonist with sedative, anxiolytic, sympatholytic, and analgesic-sparing effects, and minimal depression of respiratory function.
0 Comments
Leave a Reply. |